Interaction between erythrocyte plasma membrane and silicate dusts.

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Interaction between erythrocyte plasma membrane and silicate dusts.

Lysis of erythrocytes in vitro leading to release of hemoglobin has often been used as a convenient test system for predictive toxicological evaluation of noxious particulates encountered as pollutants in occupational and environmental atmospheres. However, in spite of several studies with silica and silicate dusts, the exact biochemical mechanism for membrane damage is not clear. Therefore, de...

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The initial phase of membrane attack by complement is the interaction between C5b6, C7, and the cell membrane that leads to the insertion of C5b-7. Here we investigate the role of sialic acid residues in the assembly of C5b-7 intermediates on erythrocyte cell membranes. We find that C5b6 binds to glycophorin, whereas C5 or C6 does not bind, and desialylation of the glycophorin abolishes C5b6 bi...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1983

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.835155